The classes will cover the pathophysiological mechanisms underlying the development of frequent non-communicable human diseases, the drugs targeting these mechanisms and unanswered questions on the topic (biomedical research). The link between the molecular, cellular, and tissue alterations and their impact on the whole organism will be highlighted as much as possible. Topics covered during classes (subject to variation depending on the group of teacher in charge): cellular therapy; cardiovascular and respiratory diseases; hemostatic disorders; endothelial dysfunction and vascular remodeling in cardiovascular diseases; neurological diseases (multiple sclerosis...) ; cancers; endometriosis ; chronic inflammatory diseases; diabetes.